The Role of Carbohydrate and Fat Intake in Male and Female Longevity: Insights from a New Study

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The Nagoya University Graduate School of Medicine in Japan conducted a study investigating the effects of extreme dietary habits related to carbohydrate and fat consumption on longevity, specifically focusing on differences in outcomes between men and women. It is important to bear in mind that this study is focused on a Japanese population, which might not directly extrapolate to Western populations due to potential differences in diet, lifestyle, and genetics.

Study Findings

1. Carbohydrate Consumption

  • Men: Men receiving fewer than 40% of their daily calories from carbohydrates faced a significantly increased risk of all-cause mortality. The source of the carbohydrates (minimally processed or refined) did not notably alter the outcomes.
  • Women: Women deriving more than 65% of their daily caloric intake from carbohydrates had a higher risk of all-cause mortality.

2. Fat Consumption

  • Men: Men consuming more than 35% of their daily calories from fats experienced a heightened risk of cancer and cardiovascular mortality. Unsaturated fat seemed particularly important; a low intake was linked to higher all-cause and cancer mortality, whereas no clear trends were identified for saturated fats.
  • Women: Women had a lowered risk of all-cause and cancer mortality with higher fat consumption, particularly saturated fats.

Remarks by Experts

Michelle Routhenstein:

  • Emphasized that the study indicated low carbohydrate diets for men and low-fat diets for women could decrease longevity.

Prof. Linda Van Horn:

  • Advised against directly applying the findings to fad diet methodologies and warned about potential misinterpretations, especially in the U.S context where there is a high obesity rate and a notable intake of ultra-processed foods.
  • Emphasized reliance on U.S. dietary guidelines that take a broader range of considerations into account.
  • Highlighted the potentially different health and socio-economic backgrounds of the Japanese cohort studied versus the U.S population.

Risk Factors and Considerations

Men and Low Carbohydrate Diets:

  • Experts suggest: Low carbohydrate diets might be lacking in essential nutrients including dietary fiber, vitamins, and minerals which could heighten the risk of certain cancers.
  • Study mentions: Such diets might encourage inflammatory pathways, increase oxidative stress, and induce more rapid biological aging.

Women and Higher Fat Diets:

  • Experts suggest: Higher fat intake might be related to the needs of women for hormone production, including estrogen, which has cardioprotective effects.
  • Study mentions: Saturated fat intake was inversely associated with mortality risk only among women, highlighting a potential area for further research.

Source of Fats

  • Saturated fats: Generally derived from animal sources including red meat, butter, and full-fat dairy products.
  • Unsaturated fats: Found in avocados, olives, and nuts among other sources.


While the study sheds light on the nuanced relationship between diet and longevity, differentiating the effects based on gender, it also presents a complex picture of nutritional requirements. It highlights the necessity to avoid extreme diets and advocates for a balanced approach to carbohydrate and fat intake to potentially enhance longevity.

Further research, including studies conducted in Western populations, is necessary to deepen the understanding of these relationships and to develop more globally applicable guidelines. It is also vital for individuals to consult with healthcare providers for personalized dietary advice.

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